A review on the application of chitosan-based polymers in liver tissue engineering.

Chitosan-based polymers have enormous structural tendencies to build bioactive materials with novel characteristics, functions, and various applications, mainly in liver tissue engineering (LTE). The specific physicochemical, biological, mechanical, and biodegradation properties give the effective ways to blend these biopolymers with synthetic and natural polymers to fabricate scaffolds matrixes, sponges, and complexes. A variety of natural and synthetic biomaterials, including chitosan (CS), alginate (Alg), collagen (CN), gelatin (GL), hyaluronic acid (HA), hydroxyapatite (HAp), polyethylene glycol (PEG), polycaprolactone (PCL), poly(lactic-co-glycolic) acid (PGLA), polylactic acid (PLA), and silk fibroin gained considerable attention due to their structure-properties relationship. The incorporation of CS within the polymer matrix results in increased mechanical strength and also imparts biological behavior to the designed PU formulations. The significant and growing interest in the LTE sector, this review aims to be a detailed exploration of CS-based polymers biomaterials for LTE. A brief explanation of the sources and extraction, properties, structure, and scope of CS is described in the introduction. After that, a full overview of the liver, its anatomy, issues, hepatocyte transplantation, LTE, and CS LTE applications are discussed.

Applications of guar gum polysaccharide for pharmaceutical drug delivery: A review.

Bio-based materials are rapidly replacing synthetic materials owing to their significant biomedical applications, easy availability, nontoxicity, biodegradability and biocompatibility. Guar gum (GG) is a plant-derived biocompatible and biodegradable polymeric compound found abundantly in nature. It is a non-ionic, hydrophilic carbohydrate and is a cost-effective hydrocolloid polysaccharide considered as a wonderful representative of the new generation of plant gums. Various composites of guar gum with other polymers have been reported in last few decades and they are extensively used in different industries like food, textile, mining, petrochemical, paper and explosives etc. Easy availability, non-toxicity, eco-friendly and biodegradable nature of GG has made it ideal candidate for for drug delivery (DD) applications. GG based hydrogels, films, scaffolds and nanoparticles have been explored widely for their DD applications. These non-toxic DD carriers can be used for targeted drug delivery. This review article directs the current efforts and improvements on GG and GG-based materials to be used in DD.

Host-guest coupling to potentially increase the bio-accessibility of 1-(2-chloroethyl)-3-cyclohexyl-1-nitrosourea by nanocarrier graphyne for brain tumor therapy, a comprehensive quantum mechanics study.

This study aimed to explore the potential of Host-Guest coupling with Nanocarrier graphyne (GPH) to enhance the bioavailability of the drug 1-(2-chloroethyl)-3-cyclohexyl-1-nitrosourea (LUM) for brain tumor therapy. The electronic, geometric, and excited-state properties of GPH, LUM, and the graphyne@1-(2-chloroethyl)-3-cyclohexyl-1-nitrosourea-complex (GPH@LUM-complex) were studied using DFT B3LYP/6-31G** level of theory. The results showed that the GPH@LUM-complex was stable with negative adsorption energy (-0.20 eV), and there was good interaction between GPH and LUM in the solvent phase. The weak interaction forces between the two indicated an easy release of the drug at the target site. The Frontier Molecular Orbitals (FMO), Charge Density Analysis (CDA), and Natural Bond Orbital (NBO) analysis supported LUM to GPH charge transfer during complex formation, and the Reduced Density Gradient (RDG) isosurfaces identified steric effects and non-bonded interactions. UV-visible examination showed the potential of the GPH@LUM-complex as a drug carrier with a blue shift of 23 nm wavelength in the electronic spectra. The PET process analysis revealed a fluorescence-quenching process, facilitating systematic drug delivery. The study concluded that GPH had potential as a carrier for delivering LUM, and different 2D nanomaterials could be explored for drug delivery applications. The theoretical study's findings may motivate researchers to investigate the practical applications of GPH@LUM-complex in oncology.

Newborn behavioral observations system in rural Pakistan: A feasibility and acceptability study.

The Newborn Behavioral Observations (NBO) system is a relationship-based tool that helps parents recognize their infant's competencies and learn their behavioral cues, with the goals of enhancing parental responsiveness and satisfaction in the infant-parent relationship. In our study, a pediatrician integrated the NBO into 44 pediatric health care visits of infants in rural Pakistan villages, under the remote guidance of two U.S.-based child psychiatrists. A clinician then gave the mothers a survey about their experience of the NBO and found that the mothers were highly satisfied, reporting greater appreciation of their infant's strengths, greater understanding of their infant's behavioral cues, stronger attachment to their infant, and greater self-confidence as a mother. In their consideration of these results, the authors explore cultural reasons for the mothers' responses and generate hypotheses to inform an outcome study of a similar intervention. This was a feasibility and acceptability study and was not randomized, had no control group, and did not use objective measures of outcome.

El sistema de Observaciones de Comportamiento del Recién Nacido (NBO)™ es una herramienta basada en la relación que se enfoca en ayudar a los padres a reconocer las competencias de su infante y aprender sus señales de comportamiento, con el propósito de mejorar la sensibilidad y satisfacción del progenitor en la relación infante-progenitor. En este estudio de probabilidad y aceptabilidad, un clínico pediatra integró el NBO dentro de 44 visitas de cuidado de salud pediátricas a infantes en aldeas rurales en Pakistán, bajo la guía remota de dos siquiatras infantiles con base en los Estados Unidos. Entonces, un clínico les dio a las madres una encuesta acerca de su experiencia con el NBO y se encontró que las madres estaban altamente satisfechas, reportando un mayor aprecio por los puntos fuertes de sus infantes, una mayor comprensión de las señalas de comportamiento de sus infantes, una más fuerte afectividad hacia sus infantes, así como una mayor auto confianza como madre. En sus consideraciones de estos resultados, los autores exploran razones culturales para las respuestas de las madres y generan hipótesis como información para un estudio de resultado de una intervención similar.

Le système d'observation comportementale du nouveau-né (Newborn Behavioral Observations, abrégé selon l'anglais NBO system™) est un outil basé sur la relation se concentrant sur l'aide aux parents à reconnaître les compétences de leur nourrisson et à comprendre leurs signaux de comportement, se donnant pour but de mettre en valeur la réaction parentale et la satisfaction dans la relation nourrisson-parent. Dans cette étude de faisabilité et d'acceptabilité un clinicien en pédiatrie a intégré le NBO dans 44 visites de santé pédiatrique de nourrissons dans des villages du Pakistan rural, sous l'orientation professionnelle à distance de deux psychiatres de l'enfance basés aux Etats-Unis d'Amérique. Un clinicien a ensuite donné aux mères un questionnaires sur leur expérience du NBO et a trouvé que les mères étaient très satisfaites, faisant état d'une plus grande appréciation des forces de leurs nourrissons, d'une plus grande compréhension des signaux de comportement de leur nourrisson, d'un attachement plus fort à leur nourrisson et d'une plus grande confiance en soi en tant que mère. Dans leur considération de ces résultats les auteurs explorent les raisons culturelles expliquant les réponses des mères et génèrent des hypothèses pour informer une étude d'une intervention similaire.

Remediation of pesticides using TiO2 based photocatalytic strategies: A review.

Nowadays, pesticides are regarded as the most dangerous of the various organic pollutants, posing substantial environmental and human threats worldwide. Pesticide contamination has become one of the most crucial environmental issues due to its bio-persistence and bioaccumulation. Different conventional methods are being utilized for pesticide removal, yet pesticides are thought to be significantly present in the environment. The development and application of sophisticated wastewater treatment methods are being pursued to remove contaminants effectively, particularly pesticides. In the past several decades, nanoscience and nanotechnology have emerged as essential tools for the identification, removal, and mineralization of persistent pesticides by employing advanced nanomaterials such as pristine titanium dioxide (TiO2), doped TiO2, nanocomposites (NCs) TiO2, and ternary nanocomposites (TNCs) TiO2 by advanced oxidation processes (AOPs). Advancement in the characteristics of TiO2 by doping, co-doping, construction of NCs and TNCs has contributed to the dramatic efficiency up-gradation by reducing band gap, solar active photocatalyst, enhancing PCA, high photostability, chemically inertness and multiple time reusability. Based on previous literature, utilizing La-TiO2 NCs photocatalyst, the mineralization of pesticide (imidacloprid) attained up to 98.17% that is almost 40-53% greater than pristine TiO2. The present review attempt to discuss the recent research performed on TiO2 based nanoparticles (NPs) and NCs for photocatalytic mineralization of various pesticides. The basic mechanism of TiO2 photocatalysis, types of reactors used for photocatalysis, and optimized experimental conditions of TiO2 for pesticides mineralization are discussed.

Temporal variation in leachate composition of a newly constructed landfill site in Lahore in context to environmental pollution and risks.

This study investigated the seasonal and temporal variations in the extent and source of physiochemical and toxic trace elements in the Lakhodair landfill site of Lahore, Pakistan. For this purpose, systematic composite samples were collected every month, consecutively for 1 year, and analyzed for different physiochemical parameters and trace elements. The results of TDS, TSS, COD, NH3-N, BOD5, sulfate, sulfides, phenolic compounds, and oil and grease were higher than the national environmental quality standard (NEQs). The concentrations of trace elements, especially Mn (1.7 mg/L) and Cd (0.05 mg/L), were above the MPL, while Fe (14 mg/L), Ni (1.6 mg/L), and Zn (6.7 mg/L) were also found higher than the NEQs in some samples. In Lakhodair leachates, the TDS, COD, NH3-N, BOD5, sulfides, and Cl- have high concentration coefficient (i.e., CC 3 to > 6), which falls in the category of considerable to high contamination and risk level, while the remaining parameters were in the category of low to moderate contamination (CC 1 to ≤ 3) and moderate risk. The lower BOD5/COD ratio (< 0.1) in spring and autumn seasons represents the active methanogenesis and anaerobic activities in the Lakhodair landfill site. The anaerobic and methanogenesis activities enhance the redox reaction as a result of CO2 emission, which increases the pH, TDS, COD, Cl-, BOD5, NH3-N, sulfides, and phenolic compounds in the leachate site. However, the lower concentrations of some trace elements in leachate may be because of an anaerobic process that may immobilize the trace elements. It is presumed that the trace elements in the Lakhodair landfill may be in a metastable state, which is difficult to leach out. It is hereby recommended that leachate produced in the Lakhodair landfill site should be handled carefully to limit the environmental and health implications.

Body Mass Index and Other Risk Factors Effects on Colon Cancer Prognosis in Pakistan.

Introduction: Asian developing countries share the burden of colorectal cancer (CRC) with rising mortality rates. This prospective study aims to apprehend the clinical relevance of age, gender, lifestyle choices (dietary habits and addiction) and body mass index (BMI) to the occurrence and progression of colon cancer (CC). Methods: A cohort of non-cancer (NC) and CC patients of South-Central Asian origin registered for screening colonoscopy or surgery at Shaukat Khanum Memorial Cancer Hospital and Research Centre (SKMCH and RC), Lahore, Pakistan, from 2015 to 2020 was identified. BMI (Kg/m2) was classified according to the World Health Organization criteria as underweight (<18.5 Kg/m2), normal weight (18.5-24.9 Kg/m2) and overweight (≥25 Kg/m2). Results: Among 236 participants, 99 (41.9%) belonged to the NC group, and 137 (58.1 %) participants had CC Overall, participants included 74 women and 162 men aged 20-85 years (mean ± SD; 49.9 ± 14.9). Notably, 46.0% of cancer patients had a family history of cancer. There was a direct relationship between CC with abnormal BMI (underweight and overweight), positive smoking history and positive family history of cancer. Conclusion: Being underweight or overweight is a potential risk factor for CC patients. The overall survival in patients with CC is clinically associated with lifestyle choices before CC diagnosis. A balanced diet, walking and other forms of exercise should be strongly recommended to the community and those undergoing screening colonoscopy.

Gender Differences in Research Project Grants and R01 Grants at the National Institutes of Health.

Objectives The National Institutes of Health (NIH), which is the world's largest funding source for research, offers various types of competitive grants depending on the duration, research type, and budget. The Research Project Grant (RPG) is the oldest mechanism for grant allocation that is used by the NIH. In this study, we explored the gender trends of NIH RPGs and R01 grants over the last two decades. Methods By utilizing the NIH Research Portfolio Online Reporting Tool (RePORT), data for gender were extracted, and the percentage of women as RPGs Investigators, R01-equivalent grant including R01 type 1 and type 2 grant awardees, from 1998 to 2019 were tabulated. The absolute change was calculated. Results From 1998 to 2019, the percentage of female RPG awardees has increased. However, the success rates for female RPG applicants have decreased during the same period. The funding and success rates for new R01 awards have been similar for both men and women, but women have been less successful at the renewal of R01-equivalent awards. Conclusion Gender disparity exists in awardees of higher RPGs, including the R01 award. This highlights the need for further actions to ensure gender parity in grant allocations at the NIH.

Gender Disparity in Grants and Awards at the National Institute of Health.

Objective The National Institute of Health (NIH) supports the academic career of scientists across the United States (U.S.). It promotes and sponsors scientists in conducting wide-ranging clinical and basic science research. Depending on the duration, research type, and budget, there are various types of grants awarded by NIH. Despite considerable advancement in biomedical sciences, female researchers remain underrepresented in obtaining NIH funding. Through this study, we aim to highlight the gender trends in NIH funding and grants. By doing this, we aim to facilitate effective future policymaking to help achieve gender parity in NIH grants and awards. Methods The data were obtained from the NIH Research Portfolio Online Reporting Tool (RePORT). The extracted data by gender were tabulated showing percentages of females as Research Grant Investigators, Research Career Development Award Recipients and Kirschstein-National Research Service Award (NRSA) Trainees and Fellows, recipients of Research Grants, Research Project Grants (RPGs), and R01 equivalent grants including types 1 or 2, over two decades (1999-2019). Absolute percentage change was also calculated and included in the tables. Results The percentage of females as NIH Research Grant Investigators has increased at centers, research centers as well as for RPGs and Small Business Innovation Research and Small Business Technology Transfer (SBIR/STTR) programs. For Research Career Development Award Recipients and Kirschstein-NRSA Trainees and Fellows, the proportion of female pre-doctoral institutional trainees, post-doctoral fellows, post-doctoral institutional trainees, mentored research career awardees, and other research career awardees have steadily increased. However, there was a decrease in the percentage of female pre-doctoral fellow awardees. The percentage of females receiving all RPGs, R01-New (type 1) and R01-Renewal (type 2) grants has also decreased.  Conclusion Despite an overall increase in the percentage of female researchers successfully receiving NIH grants and awards, they continue to lag compared to their male counterparts. With the increasing number of female doctoral graduates, it is imperative to address this disparity in NIH funding.

Expression of cornulin in tongue squamous cell carcinoma.

The aim of the study is to identify cornulin (CRNN) protein expression associated with advancement of tongue squamous cell carcinoma (TSCC). A comparison of addictive (containing potential carcinogens) versus non-addiction causative agents was expected to allow detection of differences in CRNN expression associated with TSCC. Bespoke tissue microarrays (TMAs) were prepared and immunohistochemistry (IHC) performed to determine the changes in CRNN expression in epithelial cells of node-negative (pN-), node-positive (pN+) TSCC and non-cancer patients' oral tissues. TMAs were validated by performing IHC on whole diagnostic tissues. Chi-square test or Fisher's-exact tests were used to establish significant expression differences. Analogous analyses were performed for biomarkers previously associated with TSCC, namely collagen I alpha 2 (COL1A2) and decorin (DCN) to compare the significance of CRNN. Keratinisation and its level (low, extensive) were studied in relation to CRNN so that the extent of squamous differentiation could better be assessed. IHC immunoreactive score (IRS) clustered the patients based on weak/moderate (Low (IRS ≤ +3)) or strong (High (IRS ≥ +4)) expression groups. A low expression was observed in a larger number of patients in control proteins COL1A2 (77.3%), DCN (87.5%) and target protein CRNN (52.3%), respectively. Low CRNN expression was observed in TSCC where nodes were involved (pN+: mean 1.4 ± 2.1) (p = 0.248). Keratinisation (%) was low (0% ≤ 50%) in 42.2% and extensive (1% ≥ 50.0%) in 57.8% patients. In conclusion, our study suggested that Low CRNN expression was associated with grade and lymph node metastasis in TSCC. CRNN expression is independent of addiction, however potentially carcinogenic addictive substances might be aiding in the disease progression.

Racial and gender disparities in neurology.

INTRODUCTION: The USA is a diverse society with representation from different ethnic and racial backgrounds, resulting in under-represented minorities (URMs) in various specialties of medicine. Our objective was to find the statistical ratio of URMs in the academic faculty of neurology. METHODS: This was a retrospective analysis of the American Association of Medical College database. The database covered neurology faculty members from 2006 to 2017. RESULTS: This study shows a significant change in racial representation in faculty ranks over the last 12 years. At chairperson rank, white people decreased from 86.4% to 79.8% whereas Asian, Hispanic and multiple races (non-Hispanic) simultaneously increased from 6.4% to 9.3%, 0.9% to 3.1% and 1.8% to 4.7%, respectively. At the professor rank, white people decreased from 87.4% to 81.6%, while Asians and Hispanics increased from 7.1% to 10.5% and from 0.7% to 2.1%, respectively. At the rank of associate professor, white people decreased from 81.1% to 68.3% whereas Asians, Hispanics and unknown races increased from 10.3% to 19.0%, 1.6% to 3.1% and from 2.1% to 3.5%, respectively. For the rank of assistant professor, white people decreased from 64.7% to 56.9% and Asians increased from 20.5% to 25.9%. Gender differences (men vs women) for the ranks of chairperson, professor, associate professor, assistant professor and instructors were 90.3% and 9.7%, 83.1% and 16.9%, 67.1% and 32.9%, 56.8% and 43.2%, and 48.1% and 51.9%, respectively. CONCLUSION: Over a period of 12 years the racial proportion in academic neurology has changed, but it is not proportionate to their respective increase in the population of the USA. Moreover, the portion of female faculty increased, but they are still under-represented in leadership roles. This racial and gender disparity can be addressed by well-planned interventions.

Double-hit scenario of Covid-19 and global value chains.

Due to the Covid-19 pandemic, labor force is greatly confined by quarantine (social distancing), and limited units of labor and capital are available at the workplace. Millions of employees have lost their jobs and are facing financial hardships. Likewise, capital owners have become illiquid and possibly insolvent within months. This cycle seems to continue for other factors of production as well. Even after lifting quarantines, the global trade might take months (years) to return to its actual potential. Using the GTAP-VA model, the present study simulates the impact of the double-hit scenario of Covid-19 on the global value chains and identifies production losses in different sectors of the world economy.

An Overview of Attachment Patterns: Psychology, Neurobiology, and Clinical Implications.

Attachment is an emotional bond that connects children to their caregivers. The psychology of attachment suggests that children with a stronger relationship with their primary caregivers are considered secure in their attachment patterns, whereas children with a strained relationship with their early caregivers and who had felt rejected in their childhood are considered insecure. The quality of the nurturing environment in the early stages of life of children and the relationship of parents themselves (e.g., divorce, conflict) contribute significantly to shaping a child's attachment behaviors. The neurobiology of attachment patterns includes the (a) hypothalamus, which mediates stress hormones; (b) amygdala, which controls stronger emotions such as fear; and (c) prefrontal cortex, which is responsible for emotional regulation. These areas of the brain play a vital role in children's socioemotional development. The current article reviews four attachment patterns: insecure avoidant (type A), secure (type B), insecure ambivalent/resistant (type C), and disorganized (an extreme form of insecure attachment), and explores the implications of attachment patterns on the mental health of children. [Journal of Psychosocial Nursing and Mental Health Services, 58(8), 18-22.].

Mental health considerations for children & adolescents in COVID-19 Pandemic.

Children are not indifferent to the significant psychological impact of the COVID-19 Pandemic. They experience fears, uncertainties, substantial changes to their routines, physical and social isolation alongside high level of parental stress. Understanding their emotions and responses is essential to properly address their needs during this pandemic. In this article, we highlight children's vulnerability, provide an overview of common symptoms of distress in different age groups, and summarize the interventions and resources available to promote child mental health and wellbeing during these challenging times. We advocate that prioritizing mental health including child & adolescent mental health is an essential component of any universal, community led response to COVID-19 Pandemic.

Gender distribution in psychiatry journals' editorial boards worldwide.

Gender disparity has been documented in advanced doctoral degrees, research, and academic positions, and therefore, it can logically be deduced that the gender disparity would be found in journals' editorial boards. In this study, we sought to determine the gender distribution in editorial boards of psychiatry journals worldwide. We also studied the academic achievements of editorial board members by comparing professional background, education level, and research productivity indices. We analyzed the gender of editorial members of 119 psychiatry journals from Clarivate Analytics' Journal Citation Reports. Our data included 8423 editorial board members from which we randomly selected 10% editorial board members to represent the full sample for further analyses. Overall, women represented 30.4% of editorial board and approximately 30% in each category: (1) Editor-in-chief/deputies, (2) Associate/section editors, (3) Editorial board*, and (4) Advisory board. The majority (65%) of men were M.D. psychiatrists, and women (58%) were Ph.D. psychologists. Women in editorial leadership positions (Category 1 & 2) were correlated with fewer women in editorial or advisory boards. Women had half the mean number of publications than men while serving journals with approximately the same mean impact factor. Our study results show that, besides gender disparity, gender bias does not exist in the psychiatry journal editorial boards. Given the implication of the editorial board position on science, academic advancement, and networking, this disparity remains detrimental to achieving equity, diversity, and inclusion in academic psychiatry.

Carbon footprint accounts of Pakistan: an input-output life cycle assessment model.

The Paris agreement (2015) seems a significant achievement towards a global mitigation policy to climate change. However, implementing the promised Intended Nationally Determined Contribution (INDC) targets by the participating countries has become a real challenge. In this aspect, the input-output life cycle assessment (IO-LCA) model provides an important assessment mechanism to design suitable abatement policies limiting the rising greenhouse gas (GHG) emissions. The present paper develops an IO-LCA model for Pakistan and estimates all the direct and indirect GHG emissions caused by all the production activities during all the stages of production. This task is achieved in three phases. In phase 1, the Pakistan input-output table (IOT) is constructed. In phase 2, the GHG environmental satellite accounts are created for each sector in the economy. In phase 3, the GHG emissions are linked to different categories of final demand.

A Review of Novel Antidepressants: A Guide for Clinicians.

This review article aims to provide insight into the mechanisms of action, pharmacokinetics, clinical efficacy, safety and tolerability of four novel antidepressants including desvenlafaxine, vortioxetine, vilazodone, and levomilnacipran. Following keywords are used in PubMed and Scopus to search for relevant articles: (depression) AND (psychopharmacology OR desvenlafaxine OR levomilnacipran OR vortioxetine OR vilazodone). Patients with a lack of effectiveness or tolerability to certain antidepressants may get benefit from selecting a new antidepressant with different mechanism of action. These medications can be an option in the selection of newer antidepressants. Depression may not be caused by the simple deficiency of serotonin in the brain, but rather a complex interplay of various neurotransmitters including serotonin, norepinephrine, glutamate, and histamine at certain brain areas. The above-mentioned novel antidepressants exert their therapeutic benefits by acting on multiple neurotransmitters. The complexity of underlying the neurobiological mechanism should be considered while formulating a plan of care.

Factors Predicting Length of Stay in an Adolescent Psychiatric Unit, South Bronx, NY: A Short Report.

OBJECTIVE: Mental health disorders account for around 1.8 million inpatient community hospital stays in the U.S.A. Our study aims to highlight the factors impacting the length of stay at a community hospital in the U.S.A. METHODS: We reviewed 300 randomly selected charts to examine the factors impacting the length of stay in an adolescent inpatient psychiatric unit in 2011 and 2015. All data were analyzed in SPSS v. 20 with multiple regression analysis. RESULTS: Longer length of stay among adolescents was associated with multiple psychiatric diagnoses, co-occurring medical comorbidities, not living with biological parents, history of mental illness, legal problems, substance use in the family, seclusion, restraints during current admission, and schizophrenia. CONCLUSION: Longer length of stay among adolescents in a psychiatric inpatient unit was associated with severity of psychopathology, hospital parameters and family stability.

OBJECTIF: Les troubles de santé mentale représentent environ 1,8 million d'hospitalisations en hôpital communautaire aux États-Unis. Notre étude vise à mettre en évidence les facteurs influant sur la durée de séjour à un hôpital communautaire aux États-Unis. MÉTHODES: Nous avons étudié 300 dossiers choisis au hasard pour examiner les facteurs influant sur la durée de séjour dans une unité de psychiatrie pour adolescents hospitalisés en 2011 et 2015. Toutes les données ont été analysées au moyen du programme SPSS contre 20 par une analyse de régression multiple. RÉSULTATS: Une durée de séjour plus longue chez les adolescents était associée à de multiples diagnostics psychiatriques, à des comorbidité médicales co-occurrentes, au fait de ne pas habiter avec les parents biologiques, aux antécédents de maladie mentale, aux problèmes avec la justice, à l'utilisation de substances dans la famille, à l'isolement, à la contention durant l'hospitalisation en cours, et à la schizophrénie. CONCLUSION: Une durée de séjour plus longue chez les adolescents hospitalisés dans une unité de psychiatrie était associée à la gravité de la psychopathologie, aux paramètres de l'hôpital et à la stabilité familiale.

Child psychiatry: A scientometric analysis 1980-2016.

Background: The field of child and adolescent psychiatry lags behind adult psychiatry significantly. In recent years, it has witnessed a significant increase in the publication of journals and articles. This study provides a detailed bibliometric analysis of articles published from 1980 to 2016, in the top seven journals of child and adolescent psychiatry. Methods: Using the Web of Science core collection, we selected 9,719 research papers published in seven psychiatric journals from 1980 to 2016. We utilized the Web of Science Analytics tool and Network Analysis Interface for Literature Studies (NAILS) Project scripts to delineate the general trends of publication in these journals. Then, co-citation analysis and hierarchical cluster analysis was performed using CiteSpace to map important papers, landmark theories and foci of research in child and adolescent psychiatry. Results: The field of child and adolescent psychiatry has experienced an increasing trend in research, which was reflected in the results of this study. Hierarchical cluster analysis revealed that the research foci in psychiatry were primarily studies related to the design of psychometric instruments, checklists, taxonomy, attention deficit hyperactivity disorder (ADHD), depression, PTSD, social phobia, and psychopharmacology. Moreover, several landmark studies, including the validation of a child behavior checklist, Ainsworth's empirical evidence of Bowlby's attachment theory, and adult outcomes of childhood dysregulation were published. This study also reports rapid expansion and innovation in research areas in the field of child and adolescent psychiatry from 1980-2016. Conclusions: Rapid expansion and innovation in research areas in the field of child and adolescent psychiatry has been observed, from 1980 to 2016.